Research Programmes
The work of the Creator of Metabolic Resolution Framework™ is not organised around a catalogue of products. It is organised around biological questions.
Each research programme begins by identifying a physiological disturbance, examining the signalling networks involved and exploring how nutrition or bioactive compounds may provide rational support. The programmes remain open to refinement as scientific evidence and clinical understanding evolve.
Biological Signalling
Exploring hormonal, immune, neural, metabolic, mitochondrial, mechanical and extracellular communication as an organising principle of human physiology.
Metabolic Resolution
Developing the Metabolic Resolution Framework™ as a systems-level model connecting circadian rhythm stability, neuroendocrine coordination, insulin signalling adaptability, inflammation resolution biology and mitochondrial functional integrity.
Osteoarthritis and Synovial Signalling
Investigating osteoarthritis as more than the gradual loss of cartilage — synovial inflammation, lipid mediator signalling, mitochondrial stress, altered joint mechanics, extracellular matrix remodelling, and the relationship between pain and loss of movement.
Supports mobility & functional recovery alongside clinical care
Tendon Biology and Tendinopathy
Studying mechanical loading, mechanotransduction, tenocyte activity, extracellular matrix signalling, inflammation, tissue remodelling and metabolic influences on tendon health.
Supports the development of TendonResolve™
Metabolic Dysfunction and Insulin Signalling
Exploring insulin resistance as a network-level disturbance involving skeletal muscle, liver, adipose tissue, mitochondria, inflammatory signals and neuroendocrine regulation — focused on influential signalling hubs rather than glucose alone.
Liver Health
Investigating metabolic dysfunction-associated liver changes through insulin signalling, mitochondrial substrate handling, oxidative balance, lipid trafficking, inflammatory communication and gut–liver interactions.
Healthy Ageing and Functional Longevity
Studying the communication networks that help preserve movement, metabolic adaptability, cognitive function, mitochondrial resilience and independence across the lifespan — the preservation of useful function, not merely the extension of life.
Movement, Mechanotransduction & Sports Biology
Exploring movement as a biological signal and examining how physical force becomes cellular information influencing adaptation, connective-tissue integrity, recovery and performance.
Formulation Architecture
Developing a reproducible methodology for signalling-centric nutraceutical formulation — biological mapping, identification of signalling hubs, functional ingredient selection, dose and bioavailability assessment, outcome definition and clinical validation.
Research is the disciplined pursuit
of better biological questions.